Monoclonal Antibody to CD8 (Clone: RPAT8)

Product code: 10-4091

Clone name : RPAT8
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Tuesday November 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1 Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CD8A
Gene ID : 925
Uniprot ID : P01732
Alternative Name : CD8A, MAL
Immunogen Information : Full length CD8a-alpha chain was used as the immunogen for this antibody.

CD8 membrane glycoprotein that is expressed on cytotoxic T-cells where it interacts with MHC class I processed antigens. CD8 also regulates T-cell activation and differention. CD8 has two isoforms (25 and 21 kDa) CD8 can function either as a homodimer (two alpha chains) or as a heterodimer (one alpha and one beta chain). CD8 is highly expressed in T lymphocyte, peripheral blood T-lymphocytes, thymus, spleen and lymphocyte.

FACS analysis: 0.5 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
Tissue Specificity: CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homo-dimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.
BioGrid: 107363. 14 interactions.
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