Monoclonal Antibody to CD74 (B-Cell Marker)(Clone : CLIP/813)

Product code: 36-1975

Clone name : CLIP/813
Clonality : Monoclonal
Application : FACS, IF, WBIHC
Reactivity : Human

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100 µg
$520.00 

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Shipping Info:

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CD74
Gene ID : 972
Uniprot ID : P04233
Immunogen Information : Recombinant full-length human CD74 protein

It recognizes a protein of ~35kDa, identified as CD74. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Flow Cytometry (1-2ug/million cells) (Methanol Fixed); ,Immunofluorescence (1-2ug/ml); Western Blot (2-4ug/ml) Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus, Endosome, Lysosome
Post transnational modification: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
BioGrid: 107410. 13 interactions.
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