Monoclonal antibody to CD68 (Clone: ABM53F5)-FITC Conjugated

Fig:1- Cell surface Flow analysis of hCD68 in human PBMC (Monocytes) using 0.5 µg/ 10^6 cells. Green represents isotype control (ABEOMICS);red represents anti-hCD68 FITC conjugated antibody (10-4171F).

Monoclonal antibody to CD68 (Clone: ABM53F5)-FITC Conjugated

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Product code: 10-4171-F

Clone name :	ABM53F5
Clonality :	Monoclonal
Application :	FACS
Reactivity :	Human
Conjugate :	FITC

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Format :	Purified
Amount :	100 µg
Isotype :	mouse IgG2b, k
Purification :	Protein G Chromatography
Content :	0.2 mg/ml in Tris buffer containing 0.05% Azide
Storage condition :	Store the antibody at 4°C; stable for 6 months.


Gene :	CD68
Gene ID :	968
Uniprot ID :	P34810
Alternative Name :	Macrosialin, Gp110
Immunogen Information :	A partial length recombinant protein (a.a 80-280) of CD68 was used as the immunogen for this antibody.

CD68 is a transmembrane glycoprotein which acts as a commercialized marker for human monocytes and macrophages. Its expression is thought to be regulated by a macrophage-specific promoter. However, several immunohistochemical studies have indicated that CD68 antibodies also react with other haematopoietic and non-haematopoietic cell types. It also can stain myeloid cells, dendritic cells, fibroblasts, Langerhans cells and others. In human monocytes, which produce high levels of CD68 mRNA, the gene is characterized by intramolecular ligations between the promoter and the 3' intervening region. CD68 is also used as a pan-macrophage marker for TAM (Tumor-Associated Macrophages) which always involve in carcinogenesis.

FACS: 0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Endosome membrane, Lysosome membrane
Post transnational modification:	N- and O-glycosylated.
Tissue Specificity:	Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
BioGrid:	107406. 15 interactions.