Monoclonal antibody to CD68 (Clone: ABM53F5)
Fig.1: Cell surface Flow analysis of hCD68 in human PBMC (Monocytes) cells using 0.5 µg/ 10^6 cells. Green represents isotype control (ABEOMICS); red represents anti-hCD68 antibody (10-4171). Goat anti-mouse PE conjugated secondary antibody (ABEOMICS) was used.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | mouse IgG2b, kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
CD68 is a transmembrane glycoprotein which acts as a commercialized marker for human monocytes and macrophages. Its expression is thought to be regulated by a macrophage-specific promoter. However, several immunohistochemical studies have indicated that CD68 antibodies also react with other haematopoietic and non-haematopoietic cell types. It also can stain myeloid cells, dendritic cells, fibroblasts, Langerhans cells and others. In human monocytes, which produce high levels of CD68 mRNA, the gene is characterized by intramolecular ligations between the promoter and the 3' intervening region. CD68 is also used as a pan-macrophage marker for TAM (Tumor-Associated Macrophages) which always involve in carcinogenesis.
FACS: 0.5-1 µg/10^6 cells, WB: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Endosome membrane, Lysosome membrane |
| Post transnational modification: | N- and O-glycosylated. |
| Tissue Specificity: | Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. |
| BioGrid: | 107406. 15 interactions. |
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