Monoclonal Antibody to CD63 (Late Endosomes Marker)(Clone : NKI/C3)-PE
Flow Cytometry of human CD63 on MCF-7 Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled CD63 Monoclonal Antibody (NKI/C3).
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1, kappa |
| Purification : | Affinity Chromatography |
| Content : | PE conjugated CD63 Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. |
This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood);,Immunofluorescence (1:50-1:100 for 30 minutes at RT);,
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Lysosome membrane, Late endosome membrane, Endosome, Melanosome, Secreted, Cell surface |
| Post transnational modification: | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
| Tissue Specificity: | Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. |
| BioGrid: | 107405. 37 interactions. |
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