Monoclonal Antibody to CD56-FITC conjugated (Clone: 123C3)

Product code: 10-7504-F

Clone name : 123C3
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $240.00 

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Shipping Info:

Order now and get it on Tuesday November 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, Kappa
Purification : Protein G Chromatography
Content : 0.2 mg/ml in Tris buffer containing 0.05% Azide
Storage condition : Store the antibody at 4°C, stable for 6 months.
Gene : NCAM1
Gene ID : 4684
Uniprot ID : P13591
Alternative Name : NCAM1, NCAM
Immunogen Information : The immunogen for this CD56 antibody was a membrane preparation of a small cell lung carcinoma.

CD56, a 175-220 KDa glycoprotein, is a member of the Ig super family. It is expressed as three major isoforms and consists of five Ig-like domains and two Fibronectin-type III domains in the extracellular region. The 135 kDa isoform is the basic molecule which is glycosylated or sialylated to produce the mature species. CD56 is widely expressed in nervous system, on NK cells and a specific set of Tcells. CD56+ NK cells and Tcells are unique in their ability to mediate cell-mediated cytotoxicity against certain tumor cell targets without MHC restriction. Other physiological functions of CD56 include mediating cell adhesion through homophilic and heterophilic interaction and activating intracellular signaling pathways resulting in neutrite extension and fasciculation, migration and synapses formation in brain. CD56 is also vital for neuronal development and plasticity in adult brain. It is used as a tumor marker in various cancers such as NK lymphomas and Merkel cell carcinoma. NCAM is expressed on most neuroectodermal derived lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells.

FACS: 0.5-1 µg/10^6

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
BioGrid: 110764. 33 interactions.
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