Monoclonal Antibody to CD4 (Clone: RPA-T4) APC Conjugated
Fig-1: Cell surface flow analysis of hCD4 in PBMC using 0.5 µg/10^6 cells. Green represents isotype control (ABEOMICS); red represents APC conjugated anti-hCD4 antibody (10-4090-AC).
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| Format : | Purified |
| Amount : | 100 Test |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 0.04 mg/ml in PBS containing 0.05% Azide |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. |
CD4 is a 51 kDa membrane glycoprotein that is expressed on subsets of thymocytes and mature T lymphocytes where it works as co-receptor for T-cell receptor and interacts with MHC Class II processed antigens. CD4 is also expressed on surface of monocytes, macrophages and dendritic cells. CD4 also regulates T-cell activation and differention. CD4 is identified as the cellular receptor for HIV and several other viral infections. CD4 is highly expressed in thymus, spleen and lymphocyte.
FACS analysis: 0.5 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization. |
| Tissue Specificity: | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
| BioGrid: | 107358. 94 interactions. |
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