Monoclonal Antibody to CD4 (Clone: RPA-T4) FITC Conjugated

Product code: 10-4090-F

Clone name : RPA-T4
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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  •   25 µg

  •  100 µg

  • $80.00 

  • $140.00 

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Shipping Info:

Order now and get it on Tuesday November 05, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1 Kappa
Purification : Protein G Chromatography
Content : 0.2 mg/ml in Tris buffer containing 0.05% Azide
Storage condition : Store the antibody at 4°C, stable for 6 months.
Gene : CD4
Gene ID : 920
Uniprot ID : P01730
Alternative Name : CD4
Immunogen Information : PHA-stimulated human PBMC.

CD4 is a 51 kDa membrane glycoprotein that is expressed on subsets of thymocytes and mature T lymphocytes where it works as co-receptor for T-cell receptor and interacts with MHC Class II processed antigens. CD4 is also expressed on surface of monocytes, macrophages and dendritic cells. CD4 also regulates T-cell activation and differention. CD4 is identified as the cellular receptor for HIV and several other viral infections. CD4 is highly expressed in thymus, spleen and lymphocyte.

FACS analysis: 0.5 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.
Tissue Specificity: Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
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