Monoclonal Antibody to CD31 / PECAM-1 (Endothelial Cell Marker)(Clone : SPM122)-PE

Product code: 36-1549

Clone name : SPM122
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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0.5 ml
$520.00 

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG1, kappa
Purification : Affinity Chromatography
Content : PE conjugated CD31 / PECAM-1 Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Storage condition : Store the antibody at 4°C; stable for 6 months.
Gene : PECAM1
Gene ID : 5175
Uniprot ID : P16284
Alternative Name : PECAM1
Immunogen Information : Membrane prepaRation of a spleen from a patient with hairy cell leukemia

CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

Flow Cytometry: 5ul per test per one million cellsImmunofluorescence (1:50-1:100)

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell junction
Post transnational modification: Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.
Tissue Specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).
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