Monoclonal Antibody to CD3 (Clone: OKT3) PE Conjugated
Fig-1: Cell surface flow analysis of CD3 in PBMC using 0.1 µg/10^6 cells. Green represents isotype control; red represents anti-hCD3 antibody conjugated with PE (10-4089PE).
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| Format : | Purified |
| Amount : | 100 Test |
| Isotype : | Mouse IgG2a Kappa |
| Purification : | Protein G Chromatography |
| Content : | 0.04 mg/ml in PBS with 0.05% Azide. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. |
CD3D is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma delta TCR contains, and which support surface TCR expression and transduce the TCR signal. CD3D, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK).
FACS analysis: 0.1- 0.5 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. |
| Tissue Specificity: | CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells. |
| BioGrid: | 107353. 9 interactions. |
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