Monoclonal Antibody to CD28 (Clone: CB28) FITC Conjugated
Fig-1: Cell surface Flow analysis of CD28 in PBMC (lymphocytes gated) using 0.2µg/ 10^6 cells. Green represents FITC conjugated isotype control (ABEOMICS);red represents FITC conjugated anti-hCD28 antibody (10-4137-F).
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 125 µl/100 µg in 500 µl Tris and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. |
CD28 is a type I transmembrane protein that binds through its extracellular region to B7 proteins (CD80 and CD86), which are transmembrane proteins expressed on the surface of APCs (Antigen-Presenting Cells) and are up-regulated by inflammatory signals. CD28 mediates signals that promote T lymphocyte differentiation and proliferation, and enhance antibody production of B lymphocytes. Deficiencies in CD28 pathways result in complete T lymphocyte tolerance in vitro and in vivo. Both CD4+ and CD8+ memory T cells need CD28 costimulation to achieve maximal expansion and pathogen clearance. The blockade of the CD28-B7 interaction has been used to down-regulate the activation of the immune system in autoimmune diseases. Based on the expression of the costimulatory molecule CD28 on the surface of CD8+ T cells, two different lymphocyte subgroups have been designated: antigen-primed cytotoxic T cells (CD8+CD28+ T cells) and suppressor T cells (CD8+CD28− T cells). The frequency of CD28+CD8+T cells and especially the balance between CD8+CD28+ and CD8+CD28− T cells are important in many diseases, including CHB (Chronic Hepatitis B).
FACS: 0.2-0.5 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell surface |
| Post transnational modification: | CD40LG induces tyrosine phosphorylation of isoform 3. |
| Tissue Specificity: | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| BioGrid: | 107378. 20 interactions. |
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