Monoclonal Antibody to CD20 / MS4A1 (B-Cell Marker)(L26 + IGEL/773)

Product code: 36-1894

Clone name : L26 + IGEL/773
Clonality : Monoclonal
Application : FACS, IF, IHC
Reactivity : Human

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Price
100 µg
$520.00 

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2a, kappa + Mouse IgG2a, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MS4A1
Gene ID : 931
Uniprot ID : P11836
Alternative Name : MS4A1, CD20
Immunogen Information : Human tonsil B cells (L26); Recombinant human MS4A1 protein (IGEL/773)
Recognizes a protein of 30-33kDa, which is identified as CD20. Its epitope is located in the cytoplasmic domain of CD20 and was, therefore, ascribed as CD20cy in the 5th Workshop. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin's disease, particularly of lymphocyte predominant type.

Flow Cytometry (5-10ul/million cells); ,Immunofluorescence (1:50-1:100); ,Immunohistochemistry (Formalin-fixed) (1:100-1:200 for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Cell membrane
Post transnational modification: Phosphorylated. Might be functionally regulated by protein kinase(s).
Tissue Specificity: Expressed on B-cells.
BioGrid: 107369. 15 interactions.
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