Monoclonal Antibody to CD20 / MS4A1 (B-Cell Marker)(Clone : SPM494)

Product code: 36-1891

Clone name : SPM494
Clonality : Monoclonal
Application : FACS, IF, IHC
Reactivity : Human

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0.5 ml
$520.00 

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Format : T.C. Sup.
Amount : 0.5 ml
Isotype : Mouse IgG2a, kappa
Content : Tissue culture supernatant with 0.05% Azide.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MS4A1
Gene ID : 931
Uniprot ID : P11836
Alternative Name : MS4A1, CD20
Immunogen Information : Human tonsil B cells

Recognizes a protein of 30-33kDa, which is identified as CD20. Its epitope is located in the cytoplasmic domain of CD20 and was, therefore, ascribed as CD20cy in the 5th Workshop. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.

Flow Cytometry (2-5ul/million cells); Immunofluorescence (1:100-1:200); ,Immunohistochemistry (Formalin-fixed) (1:100-1:200 for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Cell membrane
Post transnational modification: Phosphorylated. Might be functionally regulated by protein kinase(s).
Tissue Specificity: Expressed on B-cells.
BioGrid: 107369. 15 interactions.
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