Monoclonal Antibody to CD20 / MS4A1 (B-Cell Marker)(Clone : 109-3C2)
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG3, kappa |
| Purification : | Affinity Chromatography |
| Content : | 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Recognizes a protein of 30-33kDa, which is identified as CD20 (Workshop V; Code CD20.12. Workshop IV; Code B17). It recognizes an extracellular domain of CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.
Functional Studies (Order Ab without BSA & Azide); ,ELISA (For coating, order antibody without BSA);,
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell membrane |
| Post transnational modification: | Phosphorylated. Might be functionally regulated by protein kinase(s). |
| Tissue Specificity: | Expressed on B-cells. |
| BioGrid: | 107369. 15 interactions. |
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