Monoclonal Antibody to CD20 (Clone: ABM46C7) FITC Conjugated
Fig-1: Cell surface flow analysis of hCD20 in PBMC using 0.5 µg/10^6 cells. Green represents isotype control (ABEOMICS); red represents FITC conjugated anti-hCD20 antibody (10-4162F).
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2b Kappa |
| Purification : | Protein G Chromatography |
| Content : | 0.2 mg/ml in Tris buffer containing 0.05% sodium azide. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. |
CD20 is clinically validated as an immunotherapy target for B-cell lymphomas and autoimmune diseases. CD20 consists of large, intracellular, amino- and carboxyterminal portions connected by 4 membrane-spanning domains. Its high expression on malignant B cells and its reported lack of shedding from the surfacemake CD20 an ideal target for antibody-mediated killing. Anti-CD20 antibodies are believed to mediate the therapeutic effect by activation of complement-dependent cytotoxicity (CDC) and largely by antibody-dependent cellular cytotoxicity exerted by recruitment of innate immune effector cells expressing the Fcgamma receptor IIIa.
FACS : 0.5 µg / 10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell membrane |
| Post transnational modification: | Phosphorylated. Might be functionally regulated by protein kinase(s). |
| Tissue Specificity: | Expressed on B-cells. |
| BioGrid: | 107369. 15 interactions. |
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