Monoclonal Antibody to Aurora A Kinase (Clone: 1A14)(Discontinued)
Figure 1: HeLa cell cultures stained with 34-1012 antibody (green). Aurora A localizes in spindle poles and mitotic spindles at late mitosis. Counterstained is our chicken polyclonal antibody against Vimentin, 34-1126 (red). Blue is a DNA stain.
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Mouse, IgG1 |
| Content : | Antibody is supplied as an aliquot of 1 mg/ml of affinity purified antibody. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | AURKA |
| Gene ID : | 6790 |
| Uniprot ID : | O14965 |
| Alternative Name : | Aurora 2, ARK-1, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| Immunogen Information : | Full length recombinant human protein aurora A expressed in and purified from E. coli |
Western blot: 1:500-1:1,000. ICC/IF and IHC:1:500- 1:1,000.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cytoplasm, Cytoplasm, Cytoplasm |
| Post transnational modification: | Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome. |
| Tissue Specificity: | Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. |
| BioGrid: | 112666. 374 interactions. |
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