Monoclonal Antibody to Aurora A Kinase (Clone: 1A11)
Figure-1: Immunofluorescent analysis of HeLa cell cultures stained with mouse mAb to aurora A kinase,(34-1011), in green, and costained with chicken pAb to vimentin,(34-1126), in red. The blue is DAPI staining of nuclear DNA. (34-1011) antibody labels aurora A protein expressed in spindle poles at late mitosis.
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Shipping Info:
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Format : | T.C. Sup. |
Amount : | 500 µl |
Isotype : | Mouse, IgG1 |
Content : | Antibody is supplied as an aliquot of concentrated tissue culture supernatant. |
Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Gene : | AURKA |
Gene ID : | 6790 |
Uniprot ID : | O14965 |
Alternative Name : | Aurora 2, ARK-1, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
Immunogen Information : | Full length recombinant human protein aurora A expressed in and purified from E. coli |
WB: 1:100-1:500. ICC/IF and IHC: 1:100-1:500.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Cytoplasm, Cytoplasm, Cytoplasm, Cytoplasm |
Post transnational modification: | Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome. |
Tissue Specificity: | Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. |
BioGrid: | 112666. 374 interactions. |
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