Monoclonal Antibody to Arginase-1 (Clone: ABM4B35)
Fig-1: Immunohistochemical analysis of Arginase-1 in human liver tissue using Arginase-1 antibody (Clone: ABM4B35) at 15 µg/ml.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2b Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea. It is expressed in normal human liver with a high degree of specificity, concentrated in periportal hepatocytes. Arginase-1 are urea cycle enzymes used to distinguish hepatocellular carcinoma from other carcinomas. Two transcript variants encoding different isoforms have been found for this gene. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5-15 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cytoplasmic granule |
| Tissue Specificity: | Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409). |
| BioGrid: | 106878. 34 interactions. |
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