Anti-PKB alpha Monoclonal Antibody (Clone: PKB-175)
Figure 1: Anti-PKB alpha antibody 39-1088. Western blotting: Lanes: Anti PKB alpha(39-1088) at 0.5ug/ml, Lane 1: Rat Ovary Tissue Lysate at 50ug, Lane 2: PC-12 Whole Cell Lysate at 40ug, Lane 3: A549 Whole Cell Lysate at 40ug, Lane 4: MCF-7 Whole Cell Lysate at 40ug, Lane 5: HEPA Whole Cell Lysate at 40ug. Predicted band size: 56 kDa. Observed band size: 56 kDa.
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| Amount : | 100 μg/vial |
| Isotype : | Mouse IgG1 |
| Purification : | Ascites |
| Content : | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
| Gene : | Akt1 |
| Gene ID : | 24185 |
| Uniprot ID : | P47196 |
| Alternative Name : | RAC-alpha serine/threonine-protein kinase; 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1 |
| Immunogen Information : | Synthetic peptide corresponding to amino acids 461-477 of human PKB alpha/Akt1, conjugated to KLH. |
PKB alpha also knows as V-AKT murine thymoma vial oncogene homolog 1(ATK1). AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and is abrogated by mutations in the pleckstrin homology domain of AKT1. AKT1 gene is mapped to chromosome 14q32.3. Akt1/protein kinase B-alpha is critical for ischemic and VEGF-mediated angiogenesis. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Western blot : 0.25-0.5μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus, Cell membrane |
| Post transnational modification: | Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition (By similarity). |
| Tissue Specificity: | Widely expressed. Low levels found in liver with slightly higher levels present in thymus and testis. |
| BioGrid: | 246375. 13 interactions. |
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