Anti-p53 Monoclonal Antibody (Clone: BP53-12)
Figure 1: Anti-p53 monoclonal antibody(39-1049). Western blotting: HL-60 Cell Lysate.
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| Amount : | 100 μg/vial |
| Isotype : | Mouse IgG2a |
| Purification : | Ascites |
| Content : | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.
Western blot : 0.5-1μg/ml; Immunohistochemistry(Paraffin-embedded Section) : 0.5-2μg/ml; Immunohistochemistry(Frozen Section) : 0.5-2μg/ml; Immunocytochemistry : 1μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus, Nucleus, Endoplasmic reticulum, Mitochondrion matrix |
| Post transnational modification: | Sumoylated with SUMO1. Sumoylated at Lys-384 by UBC9 (By similarity). |
| BioGrid: | 246960. 10 interactions. |
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