Anti-HSP70 Monoclonal Antibody (Clone: BRM-22)

Product code: 39-1043

Clone name : BRM-22
Clonality : Monoclonal
Application : WB, IHC-P, IHC-F
Reactivity : Human

Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price
100 μg/vial
$622.00 

Add to Wish List

Shipping Info:

For estimated delivery dates, please contact us at [email protected]


Amount : 100 μg/vial
Isotype : Mouse IgG1
Purification : Ascites
Content : Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage condition : At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Gene : Hspa1b
Gene ID : 15511
Uniprot ID : P17879
Alternative Name : Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 1; HSP70.1; Hspa1b; Hcp70.1, Hsp70-1, Hsp70a1, Hspa1
Immunogen Information : HSP70 isolated from bovine brain.

Heat-shock proteins, or stress proteins, are expressed in response to heat shock and a variety of other stress stimuli including oxidative free radicals and toxic metal ions. Sargent et al. identified a duplicated HSP70 locus in the class III region of the major histocompatibility complex on 6p21.3. A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex(MHC) class III region 92 kilobases(kb) telomeric to the C2 gene. The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

Western blot : 0.5μg/ml; Immunohistochemistry(Paraffin-embedded Section) : 0.5-1μg/ml; Immunohistochemistry(Frozen Section) : 0.5-1μg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Cytoplasm
Post transnational modification: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
Tissue Specificity: Testis-specific.
BioGrid: 200452. 39 interactions.
There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products