Anti-Cyclin D1 Monoclonal Antibody (Clone: DCS-6)(Discontinued)
Figure 1: Anti-Cyclin D1 antibody(39-1029). IHC(F): Mouse Intestine Tissue.
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| Amount : | 100 μg/vial |
| Isotype : | Mouse IgG2a |
| Purification : | Ascites |
| Content : | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
D-type cyclins(cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. CyclinD1(CCND1), also known as BCL1. Expression of cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. CCND1 gene to 11q13. cyclin D1 gene can function as an oncogene. Cyclin D1 expression is regulated by the retinoblastoma protein.
Western blot : 4μg/ml; Immunohistochemistry(Paraffin-embedded Section) : 8μg/ml; Immunohistochemistry(Frozen Section) : 8μg/ml; Immunocytochemistry : 1μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Membrane |
| Post transnational modification: | Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). |
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