Anti-Cdk7/CAK Monoclonal Antibody (Clone: MO-1.1)
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| Amount : | 100 μg/vial |
| Isotype : | Mouse IgG2b |
| Purification : | Ascites |
| Content : | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
| Gene : | CDK7 |
| Gene ID : | 1022 |
| Uniprot ID : | P50613 |
| Alternative Name : | Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 protein kinase; P39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; TFIIH basal transcription factor complex kinase subunit; Cdk7; Cak, Cak1 |
| Immunogen Information : | Recombinant human Cdk7 protein. |
CDK-activating kinases(CAKs) are multisubunit proteins that phosphorylate and thus activate certain cyclin-dependent protein kinases in the regulation of cell cycle progression. Cyclin dependent kinase7(CDK7) gene is mapped to chromosome 2p15-cen. CDK7 functions in both cyclin binding and T-loop phosphorylation and that these 2 steps of CDK1 activation are mutually dependent.
Western blot : 0.25μg/ml; Immunohistochemistry(Frozen Section) : 0.5μg/ml; Immunocytochemistry : 1μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Cytoplasm |
| Post transnational modification: | Phosphorylation of Ser-156 during mitosis inactivates the enzyme. Phosphorylation of Thr-162 is required for activity. Phosphorylated at Ser-156 and Thr-162 by CDK2 (By similarity). |
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