Monoclonal Antibody to Amyloid- Beta (Clone: AB9)
Figure-1: Immunohistochemical analysis of a region of cerebral cortex from an Alzheimer’s disease (AD) patient stained with (34-1009), the signal detected with a secondary anti-mouse antibody coupled to HRP, signal revealed with DAB. Senile plaques are labeled “SPâ€. The region of the lowest of the three plaques is shown in the inset stained with the fluorescent dye thioflavin-S. This dye binds to not only the senile plaque but also a neurofibrillary tangle (NFT), the other pathological hallmark of AD, which do not contain Aβ.
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Mouse, IgG2a |
| Content : | Antibody is supplied as an aliquot of 1 mg/ml of affinity purified antibody. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | APP |
| Gene ID : | 351 |
| Uniprot ID : | P05067 |
| Alternative Name : | ABPP, APP, APPI, Alzheimer disease amyloid protein, Amyloid precursor protein, Beta-amyloid precursor protein, CVAP, Cerebral vascular amyloid peptide, PreA4, PN-II, Protease nexin-II |
| Immunogen Information : | Protein sequence 1-42, epitope is sequence 1-16 |
WB: 1:1,000-1:2,000 IF/IHC: 1:1,000.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm |
| Post transnational modification: | Amyloid-beta peptides are degraded by IDE. |
| Tissue Specificity: | Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes. |
| BioGrid: | 106848. 2117 interactions. |
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