LOX Recombinant Protein
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| Amount : | 20 µg |
| Purification : | Greater than 85% as determined by SDS-PAGE. |
| Content : | LOX protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSDDPYNPY KYSDDNPYYN YYDTYERPRP GGRYRPGYGT GYFQYGLPDL VADPYYIQAS TYVQKMSMYN LRCAAEENCL ASTAYRADVR DYDHRVLLRF PQRVKNQGTS DFLPSRPRYS WEWHSCHQHY HSMDEFSHYD LLDANTQRRV AEGHKASFCL EDTSCDYGYH RRFACTAHTQ GLSPGCYDTY GADIDCQWID ITDVKPGNYI LKVSVNPSYL VPESDYTNNV VRCDIRYTGH HAYASGCTIS PY. |
| Alternative Name : | Lysyl Oxidase, EC 1.4.3.13, Protein-lysine 6-oxidase, Lysyl oxidase. |
Source : E.coli.
LOX Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 272 amino acids (169-417a.a) and
having a molecular mass of 31.4kDa.LOX is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Lysyl Oxidase also known as LOX
is an extracellular copper enzyme which initiates the crosslinking of
collagens and elastin. LOX catalyzes
oxidative deamination of the epsilon-amino group in certain lysine and
hydroxylysine residues of collagens and lysine residues of elastin. Adding up
to crosslinking extracellular matrix proteins, LOX plays a part in tumor
suppression. Moreover, defects in LOX are the cause of autosomal recessive
cutis laxa type I, CL type I. Two transcript variants encoding dissimilar isoforms
have been found for LOX.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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