IL-6 (human):Fc (human) (Recombinant)
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| Amount : | 50 µg |
| Purification : | >=98% (SDS-PAGE) |
| Content : | Reconstitute 50µg vial in 50µl sterile water. Add 1X PBS to the desired protein concentration. Lyophilized from 0.2µm-filtered solution in PBS. |
| Storage condition : | Short Term Storage +4°C ; Long Term Storage-20°C ; Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| AA sequence : | The extracellular domain of human IL-6 (aa 30-212) is fused to the N-terminus of the Fc region of human IgG1. |
| Alternative Name : | Interleukin-6; B Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Interferon beta2; IFN-beta2 |
Source :CHO cells
Specific Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.
Endotoxin Content: <0.06EU/µg protein (LAL test; Lonza).
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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