IL-2 (human) (Recombinant) (untagged)
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| Amount : | 10 µg |
| Purification : | >=95% (SDS-PAGE) |
| Content : | Reconstitute 10µg vial with 100 µl sterile water to a concentration of 0.1mg/ml. Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5mg/ml. Further dilute in other aqueous solutions. Lyophilized from sterile 0.1% TFA, 70% acetonitrile. |
| Storage condition : | Short Term Storage +4°C ; Long Term Storage-20°C ;Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| AA sequence : | The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met. |
| Alternative Name : | Interleukin-2; Aldesleukin |
Source :E. coli
Specific Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
MW :~14kDa (SDS-PAGE)
Biological Activity: Measured in a cell proliferation assay using CTLL2 cells. The ED50 for this effect is typically 0.35-1.4ng/ml.
Endotoxin Content: <0.01EU/µg protein (LAL test; Lonza).
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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