IL 17F HEK Recombinant Protein(Discontinued)
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Amount : | 10 µg |
Purification : | Greater than 95% as obsereved by SDS-PAGE. |
Content : | The IL17F was lyophilized from 1mg/ml in 1xPBS. |
Storage condition : | Lyophilized IL-17F although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17F should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
Alternative Name : | Cytokine ML-1, IL-17F, Interleukin-17F precursor, IL17F, ML1, ML-1. |
Source : HEK.
Interleukin- 17F Human Recombinant produced in HEK cells is a glycosylated homodimer, having a total molecular weight of 38kDa.The IL17F is purified by proprietary chromatographic techniques.
IL-17F having an accession number of Q96PD4 is a cytokine that shares sequence similarity with IL17. IL-17F is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. IL-17F inhibits the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. IL-17F induces stromal cells to produce proinflammatory and hematopoietic cytokines. Intestinal IL17F gene expression is increased in active CD.IL-17A & IL-17F alleles influence the susceptibility to and pathophysiological features of ulcerative colitis independently. IL-17F and MIF gene polymorphisms are significantly associated with the development of functional dyspepsia. The initiation of IL-17F/IL-17R signaling pathway requires the receptor ubiquitination by TRAF6. IL-17F induces expression of IFN-gamma-inducible protein 10 (IP-10) by activating Raf1-mitogen-activated protein kinase 1/2-extracellular-regulated kinase 1/2-p90 ribosomal S6 kinase-cyclic AMP response element-binding protein signaling pathway.
It is recommended to reconstitute the lyophilized IL-17F in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NHDF Adult fibroblasts, and is typically 100-500ng/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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