IL 17A HEK Recombinant Protein(Discontinued)
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| Amount : | 10 µg |
| Purification : | Greater than 95% as obsereved by SDS-PAGE. |
| Content : | The IL17 was lyophilized from 1mg/ml in 1xPBS. |
| Storage condition : | Lyophilized IL-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Alternative Name : | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8. |
Source : HEK.
IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.The IL-17 is purified by proprietary chromatographic techniques.
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
It is recommended to reconstitute the lyophilized IL-17 in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts and is typically 5-25ng/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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