IL-10 (human) (Recombinant) (untagged)(Discontinued)
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| Amount : | 10 µg |
| Purification : | >=95% (SDS-PAGE) |
| Content : | Reconstitute 10µg vial with 100 µl sterile water to a concentration of 0.1mg/ml. Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5mg/ml. Further dilute in other aqueous solutions. |
| Storage condition : | Short Term Storage +4°C ; Long Term Storage-20°C ; Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| AA sequence : | Human IL-10 (aa 19-178) with a N-terminal Met. |
| Alternative Name : | Interleukin-10; Cytokine Synthesis Inhibitory Factor; CSIF |
Source :E. coli
Specific Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggest the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
MW :~18kDa (SDS-PAGE)
Biological Activity: Immobilized human IL-10 at 10µg/ml (100µl/well) can bind Cynomolgus IL-10RA-Fc. The EC50 of Cynomolgus IL-10RA-Fc is 0.24-0.56µg/ml.
Endotoxin Content: <0.01EU/µg protein (LAL test; Lonza).
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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