Human Transforming Growth Factor-beta 3
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | In solution: 10 mM acetic acid and 20% Ethanol at a concentration of 0.25 mg/mL |
| Storage condition : | Store at 4°C |
| AA sequence : | MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCS |
Source: Genetically modified E.coli.
Predicted MW:Â Dimer, 12.9/25.7 kDa (113/226 aa)
Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-beta family of proteins signal through serine/threonine kinase receptors. TGF-beta isoforms (TGF-beta 1, -beta 2, and –beta 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-beta 3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-beta 3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
Predicted MW:Â Dimer, 12.9/25.7 kDa (113/226 aa)
Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-beta family of proteins signal through serine/threonine kinase receptors. TGF-beta isoforms (TGF-beta 1, -beta 2, and –beta 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-beta 3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-beta 3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Biological Activity was determined by Inhibition of IL-4-induced HT-2 cell proliferationat <=1 ng/mL; >= 1.0 x 10^6 units/mg
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Post transnational modification: | The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive. |
| BioGrid: | 112901. 7 interactions. |
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