Human STAT6 Recombinant Protein (His Tag)(Discontinued)

Product code: 37-1303

Reactivity : Human

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Amount : 200 µg
Purification : > 90 % as determined by SDS-PAGE
Content : Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 0.3mM DTT
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Storage condition : Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA sequence : Met1-Trp847
Alternative Name : D12S1644 Protein, IL-4-STAT Protein, STAT6B Protein, STAT6C Protein,
Source : Baculovirus-Insect Cells
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p3 and the CREB-binding protein (CBP). NF-kB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-kB.

Endotoxin :< 1.0 EU per µg of the protein as determined by the LAL method

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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