Human Monocyte Chemotactic Protein-4 (CCL13)

Source: Genetically modified E.coli.
Predicted MW: Monomer, 8.6 kDa (75 aa)
Monocyte chemotactic protein 4 (MCP-4), also called CCL13, is induced by inflammatory proteins such as interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). MCP-4 is a ligand for the G protein coupled chemokine receptors CCR2, CCR3, and CCR5. MCP-4 activates signaling in monocytes, T lymphocytes, eosinophils, and basophils during inflammation and allergic responses.

Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.   

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
Tissue Specificity:	Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
BioGrid:	112260. 2 interactions.

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