Human Macrophage Inflammatory Protein-1 beta (CCL4)
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN |
Source: Genetically modified E.coli.
Predicted MW:Â Monomer, 7.8 kDa (69 aa)
Macrophage inflammatory protein-1 beta (MIP-1 beta ), also known as CCL4, is  produced by macrophages and functions as a mitogen-inducible cytokine.  MIP-1 beta signals through the chemokine receptor CCR5 to chemoattract immune cells.  MIP-1 beta induces inflammatory responses, including neutrophil superoxide production.  The MIP-1 beta and MIP-1 alpha heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).Â
Predicted MW:Â Monomer, 7.8 kDa (69 aa)
Macrophage inflammatory protein-1 beta (MIP-1 beta ), also known as CCL4, is  produced by macrophages and functions as a mitogen-inducible cytokine.  MIP-1 beta signals through the chemokine receptor CCR5 to chemoattract immune cells.  MIP-1 beta induces inflammatory responses, including neutrophil superoxide production.  The MIP-1 beta and MIP-1 alpha heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).Â
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.  Â
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Post transnational modification: | N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. |
| BioGrid: | 112254. 6 interactions. |
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