Human Macrophage Inflammatory Protein-1 alpha (CCL3)

Source: Genetically modified E.coli.
Predicted MW: Monomer, 7.8 kDa (70 aa)
Macrophage inflammatory protein-1 alpha (MIP-1 alpha), also known as CCL3, is a cytokine produced by macrophages.  MIP-1 alpha binds the chemokine receptors CCR1, CCR4 and CCR5 to induce inflammatory responses, including the recruitment of granulocytes and neutrophil superoxide production.  The MIP-1 alpha and MIP-1 beta heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1). 

Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.   

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.
BioGrid:	112252. 5 interactions.

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