Human Indian Hedgehog
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) 10 mM HCl at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | MIIGPGRVVGÂ SRRRPPRKLVÂ PLAYKQFSPNÂ VPEKTLGASGÂ RYEGKIARSSÂ ERFKELTPNYÂ NPDIIFKDEEÂ NTGADRLMTQRCKDRLNSLAÂ ISVMNQWPGVÂ KLRVTEGWDEÂ DGHHSEESLHÂ YEGRAVDITTÂ SDRDRNKYGLÂ LARLAVEAGFÂ DWVYYESKAHÂ VHCSVKSEHSAAAKTGG |
Source: Genetically modified E.coli.
Predicted MW: Monomer, 19.9 kDa (177 aa)
Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Palmitoylated. N-palmitoylation is required for N-product multimerization and full activity. |
| Tissue Specificity: | Expressed in embryonic lung, and in adult kidney and liver. |
| BioGrid: | 109765. 1 interactions. |
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