Human Growth and Differentiation Factor-5

Source: Genetically modified E.coli.
Predicted MW: Dimer, 13.7/27.4 kDa (121/242 aa)
 Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) and transforming growth factor beta (TGF-beta ) families and functions to regulate cell proliferation and differentiation in embryonic and adult tissues. GDF-5 is expressed in the central nervous system and promotes the survival of dopaminergic neurons in animal models of Parkinson's disease. GDF-5 is also important during chondrogenesis and chondrocyte differentiation.

Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Biological Activity was determined by Alkaline phosphatase activity in ATDC5 cells at <= 1.2 ug/mL; >= 8.3 x 10^2 units/mg (typical ED50 is < 25 ng/mL). Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted, Cell membrane
Tissue Specificity:	Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).
BioGrid:	113839. 30 interactions.

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