Human Growth and Differentiation Factor-15 (AF)
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | MARNGDHCPLÂ GPGRCCRLHTÂ VRASLEDLGWÂ ADWVLSPREVÂ QVTMCIGACPÂ SQFRAANMHAÂ QIKTSLHRLKÂ PDTVPAPCCVÂ PASYNPMVLIQKTDTGVSLQÂ TYDDLLAKDCÂ HCI |
Source: Genetically modified E.coli.
Predicted MW:Â Dimer, 12.4/24.8 kDa (113/226 aa)
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-beta ) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart disease, such that increased levels of circulating GDF-15 are associated with an increased risk of developing heart failure.
Predicted MW:Â Dimer, 12.4/24.8 kDa (113/226 aa)
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-beta ) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart disease, such that increased levels of circulating GDF-15 are associated with an increased risk of developing heart failure.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.  Â
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Tissue Specificity: | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. |
| BioGrid: | 114895. 13 interactions. |
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