Human GRO-alpha (CXCL1)

Source: Genetically modified E.coli.
Predicted MW: Monomer, 7.9 kDa (73 aa)
Growth regulated protein alpha (GRO-alpha), also known as CXCL1, is a chemokine that has mitogenic properties and is a neutrophil chemoattractant. GRO-alpha is secreted by macrophages, epithelial cells, neutrophils, and melanomas. GRO-alpha signals through the CXCR2 chemokine receptor and is important during spinal cord formation, inflammation, angiogenesis, tumorigenesis, and wound healing.

Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.   

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
BioGrid:	109176. 10 interactions.

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