Human Follistatin
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5 Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | MGNCWLRQAKÂ NGRCQVLYKTÂ ELSKEECCSTÂ GRLSTSWTEEÂ DVNDNTLFKWÂ MIFNGGAPNCÂ IPCKETCENVÂ DCGPGKKCRMNKKNKPRCVCÂ APDCSNITWKÂ GPVCGLDGKTÂ YRNECALLKAÂ RCKEQPELEVÂ QYQGRCKKTCÂ RDVFCPGSSTÂ CVVDQTNNAYÂ CVTCNRICPEPASSEQYLCGÂ NDGVTYSSACÂ HLRKATCLLGÂ RSIGLAYEGKÂ CIKAKSCEDIÂ QCTGGKKCLWÂ DFKVGRGRCSÂ LCDELCPDSKÂ SDEPVCASDNATYASECAMKÂ EAACSSGVLLÂ EVKHSGSCNÂ |
Predicted MW:Â Monomer, 31.7 kDa (289 aa)
Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-beta ) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-beta 1. Follistatin functions as an antagonist by binding TGF-beta family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Biological Activity was determined by Neutralization of Human Activin A induced cytotoxicity of MPC-11 cells at <= 200 ng/mL; >= 5.0 x 10^3 units/mg. Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Tissue Specificity: | Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. |
| BioGrid: | 115731. 8 interactions. |
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