Human Fibroblast Growth Factor-8
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 5 mM sodium phosphate, 50 mM sodium chloride, pH 7.5 Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | MQVTVQSSPNÂ FTQHVREQSLÂ VTDQLSRRLIÂ RTYQLYSRTSÂ GKHVQVLANKÂ RINAMAEDGDÂ PFAKLIVETDÂ TFGSRVRVRGAETGLYICMNÂ KKGKLIAKSNÂ GKGKDCVFTEÂ IVLENNYTALÂ QNAKYEGWYMÂ AFTRKGRPRKÂ GSKTRQHQREÂ VHFMKRLPRGÂ HHTTEQSLRFEFLNYPPFTRÂ SLRGSQRTWAÂ PEPR |
Source: Genetically modified E.coli.
Predicted MW: Monomer, 22.5 kDa (194 aa)
Fibroblast growth factor 8 (FGF-8) is a critical mitogenic factor that is required for normal development of the eye, ear, brain, and limb. FGF-8 functions broadly to promote cell proliferation, differentiation, and migration. Overexpression of FGF-8 increases tumor growth and angiogenesis. Human and mouse FGF-8 proteins show 100% homology.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Biological Activity was determined by 3T3 cell proliferationat <=150 ng/mL; >= 6.7 x 10^3 units/mg (typical ED50 is < 20 ng/mL). Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| BioGrid: | 108544. 124 interactions. |
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