Human FGF8a / FGF-8a Recombinant Protein(Discontinued)

Product code: 37-1322

Reactivity : Human

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Amount : 200 µg
Purification : > 95 % as determined by SDS-PAGE.
Content : Formulation Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Storage condition : Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA sequence : Gln23-Arg204
Alternative Name : AIGF Protein, FGF-8 Protein, HBGF-8 Protein, HH6 Protein, KAL6 Protein,
Source : E. coli
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.

Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.8-3.3 µg/mL.
Other pack size also available.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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