Human Connective Tissue Growth Factor
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 90% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | Â MGKKCIRTPKÂ ISKPIKFELSÂ GCTSMKTYRAÂ KFCGVCTDGRÂ CCTPHRTTTLÂ PVEFKCPDGEÂ VMKKNMMFIKÂ TCACHYNCPGÂ DNDIFESLYYÂ RKMYGDMA |
Source: Genetically modified E.coli.
Predicted MW: Monomer, 11.2 kDa (98 aa)
Connective tissue growth factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted, Secreted |
| Tissue Specificity: | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. |
| BioGrid: | 107872. 14 interactions. |
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