Human CD153 / CD30L / TNFSF8 Recombinant Protein (Fc Tag)(Discontinued)

Source : HEK293 Cells
CD3 ligand (CD3L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD3/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD3L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD3L is capable of transducing signals through CD3 on different CD3+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD3-CD3 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD3 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.

Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD30L at 20 µg/ml (100 µL/well) can bind biotinylated human CD30 with a linear range of 0.31-20 ng/ml .
Endotoxin :< 1.0 EU per µg of the protein as determined by the LAL method.
Other pack size also available.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.