Human ACVR2B(67-87) Protein, mFc Tag
Figure 1. Human ACVR2B(67-87) Protein, mFc Tag on SDS-PAGE under reducing condition.
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| Amount : | 10µg |
| Purification : | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Content : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage condition : | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Gene : | ACVR2B |
| Uniprot ID : | Q13705 |
| Alternative Name : | HTX4; ACTRIIB; ActR-IIB,Recombinant human ACVR2B(67-87) Protein with C-terminal mouse Fc tag |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Molecular Weight : The protein has a predicted molecular mass of 28.7 kDa after removal of the signal peptide. The apparent molecular mass of ACVR2B(67-87)-mFc is approximately 25-35 kDa due to glycosylation.
Tag :C-Mouse Fc tag
Molecular Weight : The protein has a predicted molecular mass of 28.7 kDa after removal of the signal peptide. The apparent molecular mass of ACVR2B(67-87)-mFc is approximately 25-35 kDa due to glycosylation.
Tag :C-Mouse Fc tag
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