Human Activin A

Source: Genetically modified E.coli.
Predicted MW: Dimer, 13.1/26.2 kDa (117/234 aa)
  Activin A is a member of the transforming growth factor beta (TGF-beta ) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin beta A chains.  Cleavage of the N-terminal propeptide renders the Activin protein biologically active.  Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.

Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Biological Activity was determined by Cytotoxicity of MPC-11 cells at <=10 ng/mL; >= 1.0 x 10^5 units/mg. Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.