HMGA2 Recombinant Protein
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| Amount : | 10 µg |
| Purification : | Greater than 80.0% as determined by SDS-PAGE. |
| Content : | HMGA2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT and 250mM Imidazole. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| AA sequence : | MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH. |
| Alternative Name : | High Mobility Group AT-Hook 2, HMGIC, High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C, High Mobility Group AT-Hook Protein, BABL, HMGI-C, LIPO, STQTL9, High Mobility Group Protein HMGI-C, HMGA2. |
Source : Escherichia Coli.
HMGA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids (1-109 a.a) and having a molecular mass of 12.8kDa.HMGA2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
High Mobility Group AT-Hook 2 (HMGA2) is a member
of the non-histone chromosomal high mobility group (HMG) family. HMG proteins perform
as architectural factors and are necessary components of the enhancesome. This protein contains
structural DNA-binding domains and may function as a transcriptional regulating
factor. In addition, identification of the deletion, amplification, and rearrangement of this
gene that are associated with myxoid liposarcoma proposes a role in adipogenesis and mesenchymal differentiation.
A gene knock out study of the mouse counterpart demonstrated that this gene is implicated
in diet-induced obesity. Among
the Diseases associated with HMGA2 are diffuse lipomatosis, and 12q14
microdeletion syndrome.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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