GARS sf9 Recombinant Protein
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| Amount : | 10 µg |
| Purification : | Greater than 80.0% as determined by SDS-PAGE. |
| Content : | GARS is supplied in 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Alternative Name : | Glycine--tRNA ligase, EC 6.1.1.14, Diadenosine tetraphosphate synthetase, AP-4-A synthetase, Glycyl-tRNA synthetase, GlyRS, GARS, HMN5, CMT2D, DSMAV, SMAD1. |
Source : Sf9 Insect Cells.
GARS Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 78,902 Dalton. GARS is expressed with a -10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
GARS is an (alpha)2 dimer which is a member of the class II family of tRNA synthetases. GARS is a glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases which charge tRNAs with their cognate amino acids. GARS catalyzes the attachment of glycine to tRNA(Gly). In addition, GARS is able to produce diadenosine tetraphosphate (Ap4A), which is a universal pleiotropic signaling molecule required for cell regulation pathways, by direct condensation of two ATPs. GARS has been demonstrated to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
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