FITC Conjugated, Anti-CD107b / LAMP-2 Monoclonal Antibody (Clone:H4B4)

Product code: 30-2085

Clone name : H4B4
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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100 tests
$433.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : LAMP2
Gene ID : 3920
Uniprot ID : P13473
Alternative Name : LAMP2
Immunogen Information : Human PBMC

CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.

Subcellular location: Cell membrane, Endosome membrane, Lysosome membrane, Cytoplasmic vesicle
Post transnational modification: O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
Tissue Specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).
BioGrid: 110114. 96 interactions.
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