CDKN2C Recombinant Protein
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| Amount : | 20 µg |
| Purification : | Greater than 95% as determined by SDS-PAGE. |
| Content : | The CDKN2C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ |
| Alternative Name : | Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4), cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, INK4C, p18, p18-INK6, p18-INK4C, CDK6 inhibitor p18, cyclin-dependent inhibitor, CDKN6, p18-INK4c. |
Source : E.coli.
CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa.CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CDKN2C is a member of the CDKN2 cyclin-dependent kinase inhibitor family. CDKN2C cooperates with CDK4 or CDK6, and inhibits the activation of the CDK kinases, therefore acts as a cell growth regulator which regulates cell cycle G1 progression. CDKN2C suppresses the cell growth and proliferation with a correlated dependency on endogenous retinoblastoma protein RB. Studies in the knockout mice show CDKN2C takes part in regulating spermatogenesis, in addition to suppressing tumorigenesis.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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